NAD+ 水平在我們年輕的時候達到頂峰，但隨著年齡的增長，它們會下降，耗盡我們的能量並使我們暴露於幾乎所有與年齡相關的功能障礙中。

1990 年代，LIDTKE 開始向藥房提供 NAD+ 處方藥。 NAD+ 的醫療潛力是顯而易見的，特別是對於神經功能衰退的問題。不幸的是，目前尚不存在顯著提高我們最需要的肌肉和腦細胞中 NAD+ 水平的技術。因此，NAD+ 似乎從未發揮其潛力。

NMN 以全新的方式工作。 NMN 是一種前體分子，可以很容易地穿過我們的細胞壁，然後我們的細胞可以在那裡製造和提高 NAD+ 水平。 NMN 可能不是第一個被發現的前體分子，但它比其他 NAD+ 前體更快地吸收到各種身體組織中。 [1]更重要的是，經過數十年的研究，NMN 似乎兌現了 NAD+ 的承諾。

NMN 存在於我們的正常飲食中，確實存在微量（每公斤食物 1 毫克），但是，食物中的少量僅有助於減緩我們 NAD+ 水平的下降，而且還不足以將 NAD+ 提升至年輕水平。顯然，隨著年齡的增長，我們需要補充。巧合的是，一項人體臨床試驗證實，NMN 的安全性遠高於普通飲食量，並且最佳水平可能仍高於目前推薦的水平。

NMN的中文全寫是β-煙酰胺單核苷酸，英文全寫則是β-nicotinamide mononucleotide。在解構NMN之前先要認識NAD＋，因為它是主宰人體新陳代謝、DNA修復、身體機能的必須元素。雖然NAD＋自然存在於人體中，但隨着年齡增長，體內的NAD+水平會逐漸下降，從而加速衰老，如在50歲時，體內的NAD+水平只有20歲時的一半。

NMN可以直接轉化成NAD+，從而促進新陳代謝、將身體機能回復至年輕狀態。如女士們最注重抗衰老美顏功效，NMN就可以活化體內的長壽蛋白Sirtuins、清除自由基，長時間服用可見面色回復紅潤光澤、更可提升肌膚彈性和減淡細紋，皮膚更年輕有活力。

Understanding NAD: the Assimilation of Precursors‚ its Generation in vivo‚ and its Effects on Aging and Human Health

NAD+ levels are at their peak when we are young‚ but they decline as we age‚ draining our energy and exposing us to nearly every age-related dysfunction.

In the 1990’s LIDTKE began providing prescription NAD+ to pharmacies. The medical potential of NAD+ was clear‚ particularly for problems of neurological decline. Unfortunately the technology did not yet exist to significantly boost NAD+ levels in our muscle and brain cells‚ where it was most needed. Hence‚ NAD+ never seemed to live up to its potential.

NMN works in an entirely new way. NMN is a precursor molecule that passes through our cell walls quite easily‚ where our cells can then manufacture and boost NAD+ levels. NMN may not be the first precursor molecule discovered‚ but it absorbs faster into a variety of bodily tissues than other NAD+ precursors.[1] More importantly‚ after many decades of research‚ NMN appears to be living up to the NAD+ promise.

NMN is found in our normal diet‚ it is true‚ in trace amounts (1 mg per kg of food)‚ However‚ the small amount found in food only helps to slow the decline of our NAD+ levels‚ and it is not nearly enough to boost NAD+ to youthful levels. Clearly‚ we need to supplement as we age. Coincidentally‚ a human clinical trial has confirmed the safety of NMN in much higher than common dietary amounts‚ and optimal levels may still prove to be higher than currently being recommended.

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